Cytochrome P450 2E1 RsaI/PstI and DraI polymorphisms are risk factors for lung cancer in Mongolian and Han population in inner Mongolia
نویسندگان
چکیده
منابع مشابه
Comparison of cardiovascular risk factors between prehypertension and hypertension in a Mongolian population, Inner Mongolia, China.
BACKGROUND There is little knowledge on comparisons of cardiovascular risk factors between prehypertension and hypertension in Mongolian populations, Inner Mongolia, China. METHODS AND RESULTS A total of 2,589 Mongolians aged 20 years and over were recruited as study participants. Demographic data, lifestyle factors, family history of hypertension, blood pressure measurements, physical examin...
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Background: Cytochrome P450 2C19 (CYP2C19) is widely involved in the metabolism of some medications. On the other hand, recent studies have shown the contribution of the CYP2C19 polymorphisms to different malignancies. We aimed to investigate the association between CYP2C19 polymorphism and occurrence of hematological malignancies by comparing the phenotype distribution of this enzyme in patien...
متن کاملEpidemiology Investigation of stroke among Mongolian and Han population aged over 45 in Inner Mongolia
To discuss the status of epidemiology of stroke in the Mongolian and Han population aged over 45 years and to understand the treatment and prevention of stroke. Data collected on stroke populations aged over 45 years in the six areas in Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The prevalence rate of stroke in patients aged over 45 years in Inner Mongolia wa...
متن کاملAnalysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer.
Human cancer risk assessment using molecular genetic techniques is a rapidly emerging field. Many studies suggest that both inherited and acquired genetic predispositions play an important role in carcinogenesis. Cytochrome P450 (CYP) 2E1 is involved in the metabolic activation of N-nitrosamines and other low molecular weight compounds. A recently described genetic polymorphism of CYP2E1 [DraI ...
متن کاملCytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer.
AIM Genetic polymorphisms of drug-metabolizing enzymes have recently been shown to affect susceptibility to chemical carcinogenesis. Cytochrome P450 2E1 (CYP2E1) enzyme catalyzes the metabolism of many procarcinogens, such as N-nitrosamines and related compounds. The gene coding for this enzyme is polymorphic and thus may play a role in gastric cardia cancer (GCC) etiology. In this hospital-bas...
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ژورنال
عنوان ژورنال: Chinese Journal of Cancer Research
سال: 2011
ISSN: 1000-9604,1993-0631
DOI: 10.1007/s11670-011-0107-2